Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers
University of Miami
Summary
The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention. The study examines whether these interventions improve cognitive and neurophysiological function, including brain metabolism, in older adults who are high-risk alcohol drinkers.
Eligibility
- Age range
- 65–84 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Between 65 and 84 years of age * English speaking * Able to provide valid informed consent, understand requirement and risk/benefits of the study and comply with study protocol * Heavy drinker defined as \>14 alcoholic drinks/week for men and \>7 drinks/week for women * Interested in reducing their alcohol consumption Exclusion Criteria: * BMI ≥ 35 * Fasting Glucose \> 125 mg/dL * Current or previously diagnosed with Type 1 or 2 Diabetes * Requires the use of insulin and/or other glucose lowering agents * Unable to fast for 12 hours * Past serious alcohol withdrawal sy…
Interventions
- Dietary SupplementVisbiome
Participants will receive 900 billion Colony Forming Units (CFU) once daily for 30 days
- BehavioralMotivational Interviewing
Participants will receive one counseling session at baseline via video call, lasting up to 30 minutes
- OtherPlacebo
Participants will receive a standard placebo designed to resemble the probiotic once daily for 30 days
Location
- University of MiamiMiami, Florida