Pilot Study of Systemic Inflammatory and Transcriptomic Responses in Patients Undergoing Open Retromuscular Ventral Hernia Repair
Northwestern University
Summary
This is a prospective, observational translational study of patients undergoing major abdominal wall reconstruction with primary fascial closure. The project integrates perioperative cytokine profiling, direct measurement of intra-abdominal pressure, and detailed clinical outcomes to define the biologic and physiologic consequences of high-tension closure. The study includes three cohorts: 1) Healthy controls (N=5), 2) High-tension fascial closure AWR patients (N=10), 3) Low-tension fascial closure AWR patients (N=10). Fascial closure tension will not be altered for the purpose of the study and will be determined by the operating surgeon as part of routine clinical decision-making.
Description
Major abdominal wall reconstruction (AWR) for large ventral hernias is among the most physiologically demanding procedures performed in general surgery. These patients often have a history of multiple prior abdominal operations, chronically altered abdominal wall mechanics and significant loss of domain. Reduction of visceral contents and abdominal wall reconstruction frequently require high-tension closure, resulting in an abrupt increase in intra-abdominal pressure (IAP) that impairs diaphragmatic excursion, reduces splanchnic perfusion, causes renal venous congestion and induces global phys…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Surgical Participants * Adults aged 18 years or older * Scheduled to undergo open retromuscular ventral hernia repair * Able to provide written informed consent Healthy Control Participants * Adults aged 18 years or older * No known inflammatory, autoimmune, or immunologic disease * Able to provide written informed consent Exclusion Criteria: * Emergent or urgent cases * Pregnancy * Chronic systemic steroid use or immunosuppressive therapy * Active infection at the time of enrollment * Known autoimmune or inflammatory disease * End-stage organ failure * Abdominal surger…
Interventions
- OtherNot applicable- observational study
There are no interventions in this observational study.
Location
- Northwestern Memorial HospitalChicago, Illinois