Rehabilitation-based Approaches to Prevent Mechanical Ventilation-induced Breathing Dysfunction
University of Florida
Summary
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.
Description
Brief periods of mechanical ventilation (MV) can degrade the function of the diaphragm, which can be a problem for older adults and people with multiple medical comorbidities. 20% of people who are placed on MV require a prolonged effort to wean back to independent breathing. The effects of MV on respiratory neural function are often unaddressed by typical clinical practices. Many aspects of clinical practice such as MV, anesthesia, opioid medication directly reduce respiratory neural drive and degrade diaphragm fiber contractile function, and these impairments can occur rapidly, persist after…
Eligibility
- Age range
- 25–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Non-smokers Sedentary or recreationally active Normal lung function No history of claustrophobia Exclusion Criteria: Current smoking or vaping Obstructive lung disease Use of antibiotics or systemic corticosteroids to treat an acute condition History of sepsis or metastatic disease Post infectious conditions that affect breathing Diagnosed with a neurological or neuromuscular condition Any use of supplemental oxygen, continuous positive airway pressure (CPAP), or other positive pressure ventilation to treat sleep apnea Cardiac disease Orthopedic conditions that impair lu…
Interventions
- DeviceSpinal cord stimulation
Transcutaneous spinal cord stimulation at 2mA intensity, for 20 minutes.
- BehavioralInspiratory Strength Training
5 sets of 5 breaths of high-intensity inspiratory strength training
- OtherSham Stimulation
Transcutaneous spinal cord stimulation at reduced intensity, lasting 1 minute at the beginning and end of a 20-minute session.
Location
- University of FloridaGainesville, Florida