The Effects of Repeated CBD Administration on Cannabis Abuse Liability and Analgesia: A Human Laboratory Study
Hannah Harris
Summary
This outpatient study examines how cannabidiol (CBD) affects the behavioral and pain-relieving effects of cannabis.
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * English-speaking, literate adults, * Male or female, * Between the ages of 18-55, * Body Mass Index from 18.5-32.0 kg/m2, * Not currently seeking treatment for cannabis or drug use, * Able to provide written informed consent and perform all study procedures, * If female, a negative pregnancy test and use of an effective form of contraception during study participation (e.g., oral contraceptive, abstinence, barrier method), * Negative urine drug test for drugs of abuse (other than cannabis) prior to every Laboratory Session, and * Otherwise healthy as determined by the in…
Interventions
- DrugCannabidiol, Medium Dose
Active Cannabidiol: Active cannabidiol (medium dose) will be administered orally for 14 days.
- DrugCannabidiol, Higher Dose
Description: Active Cannabidiol: Active cannabidiol (higher dose) will be administered orally for 14 days.
- DrugActive Inhaled Cannabis
Active Marijuana: Active Marijuana (active inhaled cannabis) will be administered through a vaporizer once per study session day (Day 1, 7, 14) per block (3 blocks total).
- DrugPlacebo Cannabidiol
Inactive/Placebo Cannabidiol: Inactive/placebo cannabidiol will be administered orally for 14 days.
- DrugPlacebo Inhaled Cannabis
Inactive/Placebo Marijuana: Experimental, non-therapeutic administration of an inactive/placebo marijuana dose will be administered through a vaporizer at each study session day (Days 1, 7, 14) per block (3 blocks total).
Location
- University of KentuckyLexington, Kentucky