A Pilot Study of an Individually Tailored, Supervised, Remotely Delivered Exercise Intervention to Improve Physical Function in Survivors of Gastroesophageal Cancer (PRECISE Study)
Jonsson Comprehensive Cancer Center
Summary
This clinical trial tests an individually tailored, supervised, remote exercise intervention to improve physical function for stage I-III gastroesophageal cancer survivors. Modern treatments for gastroesophageal cancer are effective at treating the cancer but are often aggressive, can be difficult for patients to tolerate, and can lead to significant debilitation and a loss of independence. Exercise is one promising intervention that could improve physical function in patients with gastroesophageal cancer after finishing systemic treatment. Home based exercise interventions in patients with cancer during and after chemotherapy can improve fatigue and function. An individually tailored, supervised, remote exercise intervention may improve physical function for stage I-III gastroesophageal cancer survivors.
Description
PRIMARY OBJECTIVE: I. To determine the feasibility of the exercise intervention, as measured by the percentage of participants who attend at least 80% of the exercise sessions and complete the post-intervention functional assessment. SECONDARY OBJECTIVES: I. To determine other measures of feasibility of the exercise intervention, including eligibility, recruitment, and achievement of exercise goals. II. To determine the change in measures of physical function (Short Physical Performance Battery \[SPPB\], grip strength, Two Minute Step Test \[TMST\], Activities of Daily Living \[ADL\], and…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults ≥ 18 years old at the start of study treatment * Diagnosis of early-stage (Stage I, II, III) esophageal, gastroesophageal junction, or gastric cancer. Histology can be adenocarcinoma, squamous cell carcinoma, or poorly differentiated carcinoma * Treated with at least one systemic therapy (chemotherapy or immunotherapy) and within 12 months of completing curative intent gastroesophageal cancer (GEC) treatment * Have evidence of physical function impairment, defined as a SPPB score of \< 12) at baseline * Ability to understand English and the willingness to sign a w…
Interventions
- OtherActigraphy
Ancillary studies
- ProcedureBiospecimen Collection
Undergo blood sample collection
- OtherEducational Intervention
Receive written instructions
- OtherEducational Intervention
Receive videos of strengthening exercises
- OtherElectronic Health Record Review
Ancillary studies
- OtherExercise Intervention
Compete exercise sessions
- OtherInternet-Based Intervention
Location
- UCLA / Jonsson Comprehensive Cancer CenterLos Angeles, California