Phase 1B/2A Study of the Safety and Tolerability of Human Neural Stem Cells for Huntington's Disease
Leslie Thompson
Summary
The purpose of this research study is to determine whether an implantation of hNSC-01 is a safe and tolerable study intervention for Huntington's disease. This study is the first time that hNSC-01 is being tested in people.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Please note this may not be a complete list of eligibility criteria. Inclusion Criteria: * Have decision-making capacity and be able to provide written informed consent. * Are between 18 to 65 years of age * Have genetically confirmed diagnosis of Huntington's Disease * Able to undergo MRI scans, tolerate neurosurgical procedure, blood draws and lumbar puncture. Exclusion Criteria: * Are pregnant * Test positive for human immunodeficiency virus (HIV), hepatitis C or chronic hepatitis B at Screening * Have an implanted deep brain stimulation device.
Interventions
- BiologicalhNSC-01
neural stem cell therapy
Location
- University of California, IrvineIrvine, California