Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1
Yale University
Summary
Evaluate \[18F\]GATT-44 (aka \[18F\]GAT44), to characterize its pharmacokinetic, metabolic, and in vivo binding profile, and assess the reproducibility of kinetic and binding parameters. Assess specific binding levels of \[18F\]GATT-44 by conducting a test-block study in humans. Estimate human dosimetry of \[18F\]GATT-44 by performing whole-body imaging studies.
Eligibility
- Age range
- 18–60 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Willing and able to give voluntary written informed consent; 2. Able to read and write, able to communicate effectively with the investigator, and comply with all study requirements, restrictions, and directions of the research staff; 3. Male or female, aged 18 to 60, at screening; 4. In good general health as evidenced by medical history, physical examination, ECG, serum/urine biochemistry, hematology, and serology tests; 5. Females of childbearing potential, and male subjects, must be willing to practice birth control for the duration of the study (unless medical docu…
Interventions
- Drug[ 18F]GATT-44
First in human radiotracer being evaluated in this study.
Location
- Yale University PET CenterNew Haven, Connecticut