Metric-derived Corrections Versus Clinically-derived Corrections for Children With Down Syndrome
Ohio State University
Summary
This study seeks to determine whether glasses prescriptions determined from computer analysis of detailed images of the eyes provide better vision outcomes for children with Down syndrome than prescriptions determined using routine clinical methods.
Description
The purpose of this study is to test the hypothesis that metric-derived spectacle prescriptions based on wavefront aberration measurements of the eyes of children with Down syndrome can provide an improvement in visual acuity over that obtained with spectacle prescriptions based on standard clinical prescribing techniques. Twenty-four children with Down syndrome will be enrolled to participate in this phase II clinical trial of spectacle prescriptions. The study is a randomized, cross-over design with two treatment arms that will consist of 5 study visits over the course of 12 months for each…
Eligibility
- Age range
- 5–12 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Down syndrome Age 5 to 12 years Ability to sit for study measures Able to be dilated Exclusion Criteria: Nystagmus History of Ocular or Refractive Surgery Corneal or lenticular opacities Ocular disease Anisometropic or strabismic amblyopia Contact allergy to aluminum
Interventions
- DeviceMetric-optimized spectacles
Metric-optimized spectacles are glasses made from a prescription determined by the optimization of a metric for retinal image quality, VSX, as determined by algorithms utilizing wavefront aberration measures of the eye
- DeviceRoutine Clinical Spectacles
Routine clinical spectacles are glasses made from a prescription based upon findings that are obtained during a routine eye examination, including autorefraction measures.
Location
- Ohio State UniversityColumbus, Ohio