Siemens Biomarker Multi-modality
Duke University
Summary
The purpose of this study is to see how well Photon Counting CT (PCCT) and ultrasound test results can find fat and scarring in the liver. They will be compared to MRI test results as the reference standard. Participants will get a regular CT scan on the PCCT scanner, plus a few extra pictures just for the study. They will also get an MRI, either on the same day or a different day, whichever is preferred. Participants will get an ultrasound on the same day as the MRI. If they have not had a hematocrit blood test in the past 24 hours, they will also receive one on the day of the CT scan.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age of 18 years or older * Has clinically indicated CT schedule including the liver (with contrast or with and without contrast) * Patient eligible for MR imaging * History of chronic diffuse liver disease, steatotic liver disease, and/ or liver fibrosis * Capable of consent Exclusion Criteria: * Contraindications to any of the required imaging examinations * BMI \> 45 (based on MRI scanner capacity)
Interventions
- Diagnostic TestPhoton-counting CT (PCCT)
Photon-counting computed tomography (PCCT) is a next-generation imaging technology using advanced detectors that directly count individual X-ray photons and measure their energy, rather than integrating total energy like traditional CT.
- Diagnostic TestUltrasound
Ultrasound is a safe, radiation-free imaging technique using high-frequency sound waves to visualize soft tissues, organs, and blood flow in real-time.
- Diagnostic TestMagnetic Resonance Imaging (MRI)
MRI is a noninvasive, radiation-free medical imaging technique that uses powerful magnets and radio waves to generate detailed, high-resolution 3D images of soft tissues, organs, and bones.
Location
- Duke University Medical CenterDurham, North Carolina