Exploring Tannin-Probiotic Interactions on Microbial Composition and Inflammatory Outcomes in Obesity
Prairie View A&M University
Summary
The goal of this clinical trial is to understand how gallotannin-rich (GT-rich) mangoes can reduce the inflammatory markers in obese individuals in vitro. The study will also seek to explore how gallotannins are metabolized in the gut microbiome. The main questions the research aims to answer are: * What is the impact of GT extract from mango and Lactiplantibacillus pentosus supplementation on inflammatory biomarkers in obese individuals? * Does the combination of GTs and L. pentosus exhibit synergistic effects in modulating specific microbial taxa associated with obesity and inflammation compared to either intervention alone? * Does genetic variation among individuals with obesity account for the ability to metabolize gallotannins? Researchers will compare the effects of GT extract from mango juice, a combination of GT-rich extract, and L. pentosus probiotic supplement on samples (stool) provided by obese individuals, to samples provided by a lean control group to see if gallotannins and gallotannins + probiotic supplementation reduce inflammation in obesity. Participants will * Be grouped into 4 treatment groups 1. Mango juice only 2. Mango + L. pentosus 3. L. pentosus only 4. Control (lean individuals) * Visit sample collection site one time during the study (week 1)
Description
Introduction Background Obesity is a serious, common, and expensive chronic disease, and according to a report by the Center for Disease Control and Prevention, more than 2 in 5 adults in the United States (US) live with obesity. The issue of obesity in the US is an increasing trend, as reports have shown that the prevalence of obesity among US adults aged 20 and above from 2017 to 2020 was 41.9%, rising from 30.5% in 2000. Concurrently, the prevalence of severe obesity also increased from 4.7% to 9.2%. Meaning over 100 million adults in the US are living with obesity, while more than 22 milli…
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Participants will be screened by a study before being included in the study using the following inclusion criteria. Participants must be lean or obese male or female aged 18-55 years, within the BMI ranges 18- 24.9 kg/m2 (lean) and 30-40 kg/m2 (obese) will be included. Participants will be measured for anthropometric parameters such as height and weight to confirm their BMI before being registered for the study. Exclusion Criteria: * Participants with history of acute cardiac events, stroke, or cancer, recurrent hospitalizations, drug treatment of listed conditions wit…
Interventions
- Dietary SupplementGallotannin-rich mango
This mango is high in polyphenols, specifically hydrolysable tannins, which are easily broken down by microbes in the colon. The metabolites formed can improve the gut microbiome population and also improve immune response.
- Dietary SupplementLactiplantibacillus pentosus (probiotic)
Lactiplantibacillus pentosus is a probiotic bacterium that can benefit gut health and may have additional benefits like reducing inflammation
- OtherNo Treatment Added
This intervention has no treatment added so as to serve as a control for the other interventions.
Location
- Collaborative Agricultural Research CenterPrairie View, Texas