University of California, San Francisco
This study aims to evaluate the efficacy of Laser Interstitial Thermal Therapy (LITT) in treating recurrent or progressive, low-grade gliomas (LGG) in pediatric, adolescent and young adult patients.
PRIMARY OBJECTIVE: I. To estimate the proportion of patients with recurrent or progressive LGGs who do not exhibit further disease progression at 15 months post-LITT. EXPLORATORY OBJECTIVES: I. To determine the safety and describe the toxicity of LITT in children and young adults with recurrent or progressive LGGs according to the NCI CTCAE v6.0. II. To estimate the duration of response (DOR) following LITT in children and young adults with recurrent or progressive LGGs. III. To estimate the objective response rate (ORR) following LITT in children and young adults with recurrent or progre…
Inclusion Criteria: * Participants must have recurrent or progressive pediatric LGG who have received at least one prior treatment. Prior treatment may include surgery alone and/or systemic therapy. * Participants must have histologically confirmed LGG that is recurrent or progressive after prior treatment and determined to be a candidate for LITT by central review. All patients will undergo central review prior to LITT. Any number of previous recurrences are permissible provided the participant meets other enrollment criteria. * Tumor size: up to 5 cm in largest dimension not including any c…
Perform ablation using LITT
Undergo single imaging procedure
Participants will complete questionnaires
Arctuva estimate
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