Membrane Potential Mapping with18F-TPP
Yale University
Summary
In this study, investigators propose to use PET imaging to study the pharmacokinetics of 18F-TPP and develop methods for imaging membrane potential (ΔΨT) in humans.
Description
The aims of this study are: 1. Assessment of the pharmacokinetics of primed constant infusion of 18F-TPP in humans. 2. Assessment of normal variation of membrane potential (ΔΨT) and extracellular space (ECS) in a cohort of "normal" subjects. 3. Assessment of the pharmacokinetics of bolus injection of 18F-TPP in humans. Studies will be performed on a PET/CT scanner. A separate MRI will be collected. Each scan may or may not have arterial blood sampling for measurement of the time course of radioactivity in the whole-blood, plasma and radiometabolite analysis on selected plasma samples.
Eligibility
- Age range
- 21–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Willing and able to give voluntary written informed consent * Stated willingness to comply with all study procedures and availability for the duration of the study * In good general health as evidenced by medical history, physical examination, ECG, serum/urine biochemistry and hematology tests. * If female of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study. Exclusion Criteria: * Know structural heart disease (e.g. myocardial infarction) * Abnormal and clinically…
Interventions
- Drug18F-TPP
radiotracer specific for imaging mitochondrial membrane potential (ΔΨm) administered intravenously
Location
- Yale University PET CenterNew Haven, Connecticut