Evaluating Intermittent Fasting In Individuals At High Risk ForPancreatic Cancer Undergoing Screening
M.D. Anderson Cancer Center
Summary
To learn whether an eating pattern called intermittent fasting (IF) is tolerable and feasible for individuals at high risk of pancreatic cancer and whether IF is associated with changes in biological markers, including metabolic, inflammatory, microbiome, and imaging-related markers.
Description
Primary Objectives • To assess the tolerability and feasibility of Intermittent fasting (IF) in participants at high risk for pancreatic cancer. Secondary Objectives * To assess changes in oral and gut microbiome after IF. * To assess changes in metabolomic markers after IF. * To assess changes in inflammatory markers after IF.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria * Participants ≥ 18 years old. Participants under 18 are excluded due to their potential inability to understand and consent independently to the methods required for the study drug use and its potential risks and benefits. * Participants evaluated and classified as high risk for pancreatic cancer through a High-Risk Pancreatic Cancer Clinic or High-Risk Pancreatic Cyst Clinic, based on established clinical assessment and risk stratification. * High-risk status may include one or more of the following: * Hereditary cancer syndromes or known pathogenic germline mutations…
Interventions
- Otherintermittent fasting
They will fast for 16 consecutive hours each day and have an 8-hour window for eating.
Location
- MD Anderson Cancer CenterHouston, Texas