Vonescimab for the Treatment of Previously Treated Advanced or Unresectable Leiomyosarcoma - a Phase II Trial
Memorial Sloan Kettering Cancer Center
Summary
The purpose of this study is to find out if Ivonescimab is an effective and safe treatment that causes few or mild side effects for people with advanced/unresectable leiomyosarcoma.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Male or female age ≥ 18 years at the time of informed consent * Subjects must have a histologically confirmed unresectable/metastatic LMS * Be willing and able to provide written informed consent/assent for the trial * Be willing to comply with treatment protocol * Adequate performance status: ECOG 0 - 2 * Subjects must have had at least 1 but not more than 3 prior lines of systemic therapy for their LMS. Patients who decline the standard of care first-line systemic therapy will be eligible for this trial. Prior adjuvant therapy will not count provided it was completed m…