A Randomized Controlled Trial Comparing Suzetrigine and Acetaminophen for Reducing Pain During Local Anesthetic Infiltration and Head Frame Application
Wake Forest University Health Sciences
Summary
Local anesthetic infiltration is a primary source of acute pain during stereotactic procedures.
Description
Frame placement can be painful even with local numbing medicine. This study compares two oral medications-Suzetrigine (an FDA-approved (January 30, 2025) non-opioid, non-addictive medication used to treat moderate-to-severe acute pain in adults)) and acetaminophen (Tylenol)-to see which is more effective at reducing this pain. Both Tylenol and Suzetrigine are currently being used for pain prevention during head frame placement. This study is being conducted to determine if one offers greater relief than the other.
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients scheduled for a standard of care procedure requiring a stereotactic head frame to be placed Exclusion Criteria: * Patients not scheduled for a standard of care procedure requiring a stereotactic head frame to be placed will not be approached
Interventions
- DrugSuzetrigine
100mg - Medication is self-administered at home on an empty stomach approximately 1-6 hours prior to the procedure.
- Drugacetaminophen
1000mg - Medication is self-administered at home on an empty stomach approximately 1-6 hours prior to the procedure.
Location
- Wake Forest University Health SciencesWinston-Salem, North Carolina