Study detail
RecruitingPhase 1
A Phase 1, Open-Label, Two-Period Fixed Sequence Study to Evaluate the Effects of a Single Oral Dose of Ulonivirine (MK-8507) on the Single-Dose Pharmacokinetics of Atorvastatin and Metformin in Healthy Adult Participants
Merck Sharp & Dohme LLC
Summary
Researchers want to learn about ulonivirine when given with atorvastatin and metformin in healthy people. The goal of this study is to compare the amount of atorvastatin and metformin in a person's body over time when given with and without ulonivirine.
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- Yes
Detailed criteria
Inclusion Criteria: * Has body mass index (BMI) 18.0 and ≤ 32.0 kg/m\^2 * Is medically healthy with no clinically significant medical history, physical examination, clinical laboratory profiles, vital signs, and electrocardiogram (ECG) Exclusion Criteria: * Has history of cancer (malignancy) * Positive results for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV)
Interventions
- DrugAtorvastatin
Oral tablet
- DrugMetformin
Oral tablet
- DrugUlonivirine
Oral tablet
Location
- Celerion ( Site 0001)Tempe, Arizona