Memorial Sloan Kettering Cancer Center
The researchers are doing this study to test the safety of BMS-986504 in combination with standard disease-specific anticancer medication in people with metastatic/advanced unresectable MTAP-deleted solid tumor cancer.
Inclusion Criteria: * Documentation of Disease: * Patients must have pathologic confirmation of one of three diseases: * Diffuse pleural mesothelioma (DPM) * Gastroesophageal carcinoma (GEC) including adenocarcinoma or squamous cell carcinoma of the esophagus, gastroesophageal junction, or stomach. * PD-L1 CPS ≥1 (using clone 73-10, DAKO) * HER2 overexpression negative (using clone 4B5, Ventana): HER2 IHC 0-1+, or HER2 2+ with ISH showing HER2:CEP17 ratio \<2 and average HER2 copy number \<6.0 signals/cell * Urothelial carcinoma (UC) * Archival tissue is acceptable; diagnosis may be confirmed…
BMS-986504 PO daily
Ipilimumab (1mg/kg Q6wk)
Nivolumab (360mg flat dose Q3wk)
are continued until disease progression or intolerance
are continued until disease progression or intolerance
are continued until disease progression or intolerance
Gemcitabine are given for a maximum of 6 cycles
Platinum are given for a maximum of 6 cycles