A Phase II Study of Mosunetuzumab in Combination With Pirtobrutinib in Patients With Relapsed or Refractory Waldenstrom Macroglobulinemia (MPOWER)

Inclusion Criteria: * Subjects aged ≥ 18 years with documented diagnosis of WM with the definition of measurable disease * Subjects who are able to comply with the study protocol. * Subjects with relapsed or refractory WM who have received at least one prior line of therapy. * Must have received prior treatment with covalent BTK inhibitor or have declined such treatment. * Prior autologous stem cell transplant is permitted if completed ≥ 100 days prior to treatment. * Prior allogeneic transplants are not permitted. * Subjects must have an indication for treatment per IWWM * ECOG Perfor…