Pilot Study to Investigate Brain Targets for Neuromodulation in Obsessive-compulsive Disorder
University of Pennsylvania
Summary
The investigators will conduct a pilot study to evaluate the safety and feasibility of low-intensity focused ultrasound on obsessive-compulsive disorder (OCD) symptoms when delivered to subcortical brain targets. The investigators will use the ATTN201 device to deliver single sessions of unfocused and focused ultrasound to up to three brain targets over 4 study visits and assess the intervention through self-rated scales of OCD symptoms.
Eligibility
- Age range
- 18–60 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1\. Participants must be enrolled in the IRB #853085 study The inclusion criteria for the IRB #853085 study, which are also included in this trial are: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Adults aged 18-60 years old 2. Chronic OCD (5 years preceding date of enrollment), diagnosed as per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition guidelines (DSM-5) 3. Presence of obsessions, compulsions, or both time-consuming obsessions and compulsions that take more than one hour a…
Interventions
- DeviceLow Intensity Focused Ultrasound
Low-intensity focused ultrasound (LIFU) will be administered using the Attune ATTN201 device. This intervention is characterized by a multifocal approach targeting three specific subcortical regions: the subthalamic nucleus (STN), the dorsal anterior cingulate cortex (dACC), and the ventral striatum (VS+). Unlike clinical treatment trials, this is a target-engagement pilot study where each participant receives single sessions of sonication at these specific coordinates to evaluate acute physiological and symptomatic changes. The intervention includes a within-subject sham-controlled component, where the device is positioned identically but no ultrasound energy is delivered.
Location
- University of PennsylvaniaPhiladelphia, Pennsylvania