A Phase 1, Randomized, Placebo-Controlled, Double-Blind, Multiple- Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HMS1005 in Participants With Type 2 Diabetes

Inclusion Criteria: 1. Males or females, of any race, between 18 and 65 years of age, inclusive. 2. Body mass index between 18 and 38.0 kg/m2, inclusive. 3. Females will not be pregnant or lactating, and females of childbearing potential and males will agree to use contraception as detailed in Appendix 3. 4. T2DM, as determined by the ADA Standard Care Diagnostic Criteria 2025, and * are drug naïve, treated with diet and exercise, or * have been on a stable dose of ≤2000 mg metformin for ≥1 month, and/or * have been on a stable dose of other antidiabetic medications for ≥90 days. 5.…