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Phase 1
A Phase 1/2 Open-label Intrathecal Administration of MELPIDA to Determine Its Safety and Efficacy for Patients with Spastic Paraplegia Type 50 (SPG50) Caused by Mutation in the AP4M1 Gene.
MELPIDA is proposed for the treatment of subjects with SPG50 and targets neuronal cells to deliver a fully functional human AP4M1 cDNA copy via intrathecal inj…
Spasticity, MuscleMicrocephalyIntellectual Deficiency+3 more
Elpida Therapeutics SPCNCT05518188
Observational
Targeted Fortification of Donor Breast Milk in Preterm Infants
This study is a randomized controlled trial comparing standard fortification of donor breast milk to targeted fortification of donor breast milk in preterm inf…
Prematurity; ExtremeFailure to Thrive in NewbornGrowth Retardation+2 more
Columbia UniversityNCT04294368
Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation
Optimal diagnostic management and underlying pathophysiological mechanisms of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin…
Twin; Pregnancy, Affecting Fetus or NewbornFetal Growth RetardationTwin Monochorionic Diamniotic Placenta+1 more
Leiden University Medical CenterNCT05952583