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Phase 1
A Cross-over Randomized Control Trial to Evaluate the Retinaldehyde Dehydrogenase Inhibitor, Disulfiram, in Improving Retinal Sensitivity in Eyes Affected by Inherited Retinal Degeneration
Aberrant retinoic acid signaling driven by the degenerating outer retina leads to pathological changes to the inner retina. The resulting hyperactivity of reti…
Inherited Retinal Dystrophy Primarily Involving Sensory Retina
University of WashingtonNCT05626920
Phase 1
Oral Metformin for Treatment of ABCA4 Retinopathy
Background: ABCA4 retinopathy is a genetic disease in which the ABCA4 protein is absent or faulty. It can cause waste material to collect in the eye and may c…
ABCA4 RetinopathyStargardt DiseaseRetinal Dystrophy+1 more
National Eye Institute (NEI)NCT04545736