National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Participants in this study will be patients diagnosed with or suspected to have a thyroid function disorder. These conditions may include: hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves' Dermopathy, and thyroid-stimulating hormone (TSH) secreting pituitary adenomas. The main purpose of this study is to further understand the natural history, clinical presentation, and genetics of thyroid function disorders. Many of the tests performed are in the context of standard medical care that is offered to all patients with thyroid function disorders. In addition, blood and tissue samples may be taken for research and genetic studies....
Study Description: Participants with known or suspected thyroid function abnormalities (hyperthyroidism, hypothyroidism, extreme iodine deficiency, and inherited forms of hypothyroidism resulting from abnormalities in the expression of genes coding for the TSH- beta subunit, Pax-8, TTF-2, Pit-I, Tg, PDS, and NIS) and/or with thyroid function tests abnormalities. Participants undergo routine examinations and other standard diagnostic procedures, as clinically indicated. Blood, urine, and leftover thyroid or pituitary tissue specimens will be collected for research. Objectives: 1. To understa…
* INCLUSION CRITERIA: The categories of subjects eligible to participate in this study include: 1. Participants with known or suspected thyroid abnormalities (e.g. hypothyroidism, hyperthyroidism, extreme iodine deficiency, and inherited forms of hypothyroidism resulting from abnormalities in the expression of genes coding for the TSH- beta subunit, Pax-8, TTF-2, Pit-I, Tg, PDS, and NIS). 2. Participants with thyroid function test (TFT) abnormalities due to: * Non-thyroidal illness * Abnormalities of serum TH binding proteins leading to euthyroid hyperthyroxinemia or hypotriiodothyron…
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