Molecular and Genomic Profiling of Head and Neck Tumors to Explore Biomarkers Associated With Prognosis and Response to Therapy
Montefiore Medical Center
Summary
The purpose of this study is to study the genetic profile of head and neck tumors and their relationship to treatment response and outcome
Description
Previous research by our group using genetic microarray analysis of HNSCC and normal keratinocytes has identified two distinct groups of genetic expression based on clustering patterns of a subgroup of genes. Clinical data was summarized for each group and overall, patient segregation by gene expression profiling was a better predictor of outcome than clinicopathological variables. Further analysis identified 375 genes that discriminate between the genotypic subtypes of HNSCC. Overall, our preliminary data has shown that the pattern of global gene expression in a HNSCC specimen can be used as…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * actual or suspected malignant or non-malignant tumors of the head and neck * planned biopsy and/or resection, or availability of paraffin embedded or stored frozen tumor tissue for non-genetic analysis Exclusion Criteria: * insufficient tissue available for both standard diagnostic evaluation and study specimen
Location
- Stelby AugustineThe Bronx, New York