Vanderbilt University Medical Center
Our experiments are designed to test the overall hypothesis that position-dependent or water-dependent intra-ocular pressure (IOP) spikes occur in humans, and that these challenge ocular homeostasis.
Glaucoma is the second leading cause of blindness in the United States, yet its pathogenesis is poorly understood. This is an insidious disorder since the loss of peripheral vision which occurs first usually is not noticed by the victim. Approximately 1 million people in the United States have glaucoma, but are not aware of it. Glaucoma is not always associated with elevated intraocular pressures so that vision screenings which measure just intraocular pressure without assessing the optic nerve will also miss these patients with glaucomatous damage. Therefore, patients are often diagnosed only…
Inclusion Criteria: * Patients with autonomic dysfunction * Patients with open-angle glaucoma * Patients with normal-pressure glaucoma * Normal subjects Exclusion criteria: * Medical students * Prisoners * Pregnant women
Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes
Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.
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