Biliary Atresia Study in Infants and Children (BASIC)
Arbor Research Collaborative for Health
Summary
Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following aims: To identify the gene or genes implicated in the etiology of BA; To characterize the natural history of the older, non-transplanted child with BA.
Description
Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. A variety of genetic, autoimmune and environmental influences have been hypothesized to be important. Most studies to date have focused on the neonate and young child with BA, yet the older surviving child with BA can provide important information about genetics, as well as, natural history. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following hypotheses: Hypothesis 1: A…
Eligibility
- Age range
- 0–20 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Participants need to have a confirmed diagnosis of BA determined by chart review including review of pertinent diagnostic biopsy reports, radiologic reports and surgical reports (if surgery was performed). 2. Participants need to be \>6 months of age up to and equal to the age of 20 (participants enrolled at 20 years of age will have one visit). 3. Participants with their native liver. 4. Parent, guardian or participant (if 18 years of age or older) is willing to provide informed consent and, when appropriate, the participant is willing to assent. Exclusion Criteria:…
Locations (16)
- Children's Hospital of Los AngelesLos Angeles, California
- University of California at San FranciscoSan Francisco, California
- Children's Hospital ColoradoAurora, Colorado
- Children's Healthcare of Atlanta - Emory UniversityAtlanta, Georgia
- Ann & Robert H. Lurie Children's Hospital of ChicagoChicago, Illinois
- Riley Children's HospitalIndianapolis, Indiana