Genetic Studies in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Boston Children's Hospital
Summary
Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another. In this study, the investigators are collecting genetic material via blood or saliva and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS. The investigators are enrolling inviduals with IC/BPS and their family members (family members with and without IC like symptoms). Travel to Boston not required.
Description
The investigators are trying to identify a genetic cause of interstitial cystitis (IC)/bladder pain syndrome (BPS). The investigators are looking to enroll individuals with a clinical diagnosis of IC/BPS and their family member. The investigators are attempting to determine if there is a connection between symptoms of IC/PBS and changes in specific genes or a pathway of connected genes. The investigators will use several genetic technologies including but not limited to; linkage analysis, genome sequencing, RNAseq and candidate gene studies to try to identify the cause of IC/BPS. Once the inve…
Eligibility
- Age range
- 1+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosis of IC/BPS * Males and females of any age * Urinary frequency - more than 1X/hour, and/or * Dysuria, and/or * Pelvic, suprapubic, or abdominal pain - for 3 months or longer * Nocturia * Normal urinary stream (by history) * No evidence of active bacterial UTI (no pyuria \& negative urinary culture for last 3 months) * First degree relative of someone with above symptoms Exclusion Criteria: * Major structural/anatomical urinary tract abnormalities by ultrasound * Underlying inborn conditions affecting the urinary tract * Surgery/chemotherapy affected pelvic area…
Location
- Boston Children's Hospital (BCH)Boston, Massachusetts