Genetics of Primary Graft Dysfunction
University of Pennsylvania
Summary
Primary graft dysfunction (PGD) is a severe lung injury that can occur in the days following lung transplant surgery. The purpose of this study is to identify genetic factors that may put someone at risk for developing PGD.
Description
PGD is a severe complication that affects up to 25% of lung transplant patients following surgery. Pulmonary edema, which is an abnormal build-up of fluid in the lungs, and hypoxemia, which is low blood oxygen levels, are two common symptoms that individuals with PGD experience. Treatment for this condition is often expensive, and it is the leading cause of death following lung transplant. Many potential donors and recipients are considered unsuitable for lung transplant because of concern for the development of PGD. Therefore, the ability to accurately predict which individuals are at risk fo…
Eligibility
- Age range
- 15–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Undergoing lung transplant surgery Exclusion Criteria: \- Individuals undergoing multi-organ transplantation except heart/lung transplants
Location
- University of PennsylvaniaPhiladelphia, Pennsylvania