Molecular and Genetic Analysis of Lung Cancer
Massachusetts General Hospital
Summary
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This clinical trial is analyzing the DNA in blood and tissue samples from patients with lung cancer.
Description
OBJECTIVES: * Assess the role of genetic polymorphisms in lung-cancer risk in patients with lung cancer. * Assess the role of germline polymorphisms in DNA repair genes, p53 pathway genes, and a matrix metalloproteinase gene (tumor invasion factor) in lung-cancer risk, after adjusting for potential confounders. * Assess the roles of gender and age in the genetic susceptibility of lung cancer. * Assess the role of genetic polymorphisms in modifying the diet-lung cancer risk association (gene-diet and exploratory gene-gender-diet and gene-gene-diet interactions). * Assess the role of polymorphi…
Eligibility
- Age range
- 18–120 years
- Sex
- All
- Healthy volunteers
- Yes
DISEASE CHARACTERISTICS: * Patient: * Newly diagnosed primary lung cancer * Patient at Massachusetts General Hospital (MGH) or Boston Medical Center Cancer Center PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified EXCLUSIONS: Vulnerable populations are excluded. Patients with metastasis from another site to lung or mesothelioma are excluded.
Locations (2)
- Massachusetts General HospitalBoston, Massachusetts
- Harvard School of Public HealthBoston, Massachusetts