Clinical Risk Factors for Primary Graft Dysfunction
University of Pennsylvania
Summary
Primary graft dysfunction (PGD) is a severe lung complication that can occur in the days after lung transplant surgery. This study will analyze blood samples to determine if high levels of certain chemicals may increase the risk of developing PGD after a lung transplant.
Description
PGD is a severe complication that affects up to 25% of lung transplant patients following surgery. Pulmonary edema, which is an abnormal build-up of fluid in the lungs, and hypoxemia, which is low blood oxygen levels, are two common symptoms that individuals with PGD experience. Treatment for PGD is often expensive, and it is the leading cause of death following lung transplantation. Many potential lung donors and recipients are considered unsuitable for lung transplantation because of concern for the development of PGD. Increased levels of chemicals that are involved in bleeding and clotting,…
Eligibility
- Age range
- 13–68 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Undergoing lung or combined heart and lung transplantation Exclusion Criteria: * Undergoing combined organ transplantation other than heart and lung transplantation
Location
- University of PennsylvaniaPhiladelphia, Pennsylvania