Genetic and Environmental Risk Factors for Hemorrhagic Stroke
State University of New York at Buffalo
Summary
The purpose of this study is to find risk factors for hemorrhagic stroke.
Description
The proposed research builds on the most robust, statistically significant and replicated association identified to determine the mechanism by which it may relate to intracerebral hemorrhage (ICH) risk. Given that ICH is an extreme phenotype on a spectrum of manifestations of cerebral small vessel disease, the findings that emerge from our proposed studies offer the promise of broad impact for research and treatment in a wide variety of cerebrovascular disorders. In the genetic epidemiology of hemorrhagic stroke, we propose to perform an in-depth fine-mapping of the entire 1q22 genomic region…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age 18 or older * Resident (6 months or longer) within the recruitment center * Fulfillment of the criteria for spontaneous ICH * No evidence of trauma, brain tumor/metastases or infectious processes as a cause of the hemorrhage * Ability of the patient or legal representative to provide consent for an interview, blood pressure determinations and DNA sampling Exclusion Criteria: * N/A
Locations (7)
- University of Illinois ChicagoChicago, Illinois
- Baptist Health LouisvilleLouisville, Kentucky
- University of MarylandBaltimore, Maryland
- Massachusetts General HospitalBoston, Massachusetts
- Columbia UniversityNew York, New York
- Duke UniversityDurham, North Carolina