Circulating Markers for Ischemic Heart Disease
UConn Health
Summary
The purpose of this research is to determine if two proteins in the blood are increased during acute myocardial infarction and whether their levels are higher in those who develop heart failure than those who do not. These two proteins are produced and potentially released when the heart muscle is damaged. They may then be released into the blood and be detected by standard method in the research laboratory. At this time, detection of an increase in these proteins in the blood is not known to be associated with any disease or myocardial infarction.
Description
Hypotheses, Objectives and Aims: Hypotheses:Caspase-3, cleaved and activated, and dystrophin can be detected in human circulation. The levels of these two markers are elevated during acute myocardial infarction. Furthermore, the levels of these two proteins are greater in those who develop heart failure than those who do not. Objectives: * To determine whether cleaved caspase-3 and dystrophin can be detected in human circulation after an acute myocardial infarction * To compare serum levels of these two markers in those who develop heart failure and those who do not Scientific Background a…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * men and women, 18 years of age and over with acute myocardial infarction (determined by positive cardiac markers -CKMB/ troponin) with or without heart failure (dyspnea, rales, edema, elevated jugular venous pressure, ascites). * Heart failure can be diagnosed using imaging evidence such as dilated heart, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures * A control group of male subjects age 60 and older without history of MI or heart disease Exclusion Criteria: * Subjects unable…
Location
- University of Connecticut Health CenterFarmington, Connecticut