Molecular Fingerprinting of Lung Cancer
Vanderbilt-Ingram Cancer Center
Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer. PURPOSE: This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer.
Description
OBJECTIVES: * Develop statistical and computational methods for modeling the relationships between multiple variable protein and RNA expression data and clinical endpoints using both supervised and unsupervised classification and pattern recognition approaches. * Determine protein and RNA expression fingerprints on completely resected non-small cell lung cancer without prior chemotherapy. * Correlate protein and RNA expression fingerprints with T-stage and nodal involvement at the time of surgery, and collect outcome data to allow correlation with recurrence (local and/or distant) and surviva…
Eligibility
- Age range
- 18–120 years
- Sex
- All
- Healthy volunteers
- No
Inclusion criteria * Diagnosis of non-small cell lung cancer * Clinical stage I and II disease * Resectable disease and complete surgical resection planned * Treated on companion studies at Vanderbilt University, the Veterans Administration hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network * Tumor specimen samples must be available at resection Exclusion criteria * Chemotherapy before surgery * Radiotherapy before surgery
Interventions
- Geneticgene expression analysis
Blood and lung tissue collection
- Geneticmicroarray analysis
Blood and lung tissue collection
- Geneticprotein expression analysis
Blood and lung tissue collection
- Otherbiologic sample preservation procedure
Blood and lung tissue collection
- Otherlaboratory biomarker analysis
Blood and lung tissue collection
- Othermatrix-assisted laser desorption/ionization time of flight mass spectrometry
Blood and lung tissue collection
Locations (3)
- Dan Rudy Cancer Center at Saint Thomas HospitalNashville, Tennessee
- Veterans Affairs Medical Center - NashvilleNashville, Tennessee
- Vanderbilt-Ingram Cancer CenterNashville, Tennessee