Collection of Blood From Patients With Prostate Cancer
National Cancer Institute (NCI)
Summary
Background: * It is not fully understood why prostate cancer in some men becomes androgen-independent (no longer responds to anti-androgen medication), but genetics likely plays an important role. * Genes contain the hereditary information that is passed down from parents to children. Although everyone has the same set of genes, individuals can have different forms of the same gene. * Differences in genes may explain, at least in part, why some people develop a more aggressive form of prostate cancer than others. Objectives: -To obtain blood samples from patients with prostate cancer to try to identify gene differences associated with progression to the androgen independent state. Eligibility: -All participants participating in NCI prostate cancer protocols. Design: * Participants with prostate cancer are evaluated in the NCI s Medical Oncology Clinic. * Blood samples are collected at the initial visit or at follow-up visits. * DNA (genetic material) and white blood cells are extracted from these samples to be used for genotyping and establishment of cell lines. * Gene variations are correlated with prostate cancer prognosis and prognostic indicators.
Description
Objectives: -To obtain blood samples from patients with prostate cancer for genotyping analyses. Eligibility: \- All patients seen in the NCI prostate cancer clinic are eligible. Design: * Patients with a prior diagnosis of prostate cancer will be evaluated in the GMB Clinic, NCI. * Blood samples will be collected after the participant signs the protocol consent form. In general, blood will be collected for genomic DNA one time for this study. Extra samples may be requested if the original sample was not enough. The additional sample can range from one to two tubes of blood (approximately…
Eligibility
- Age range
- 18+ years
- Sex
- Male
- Healthy volunteers
- No
* INCLUSION CRITERIA: Individuals 18 years of age and older are eligible. Individuals with a diagnosis of prostate cancer are eligible. EXCLUSION CRITERIA: Children are not eligible.
Location
- National Institutes of Health Clinical CenterBethesda, Maryland