Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy
Proton Collaborative Group
Summary
The purpose of this study is to see what effects, good and/or bad, proton radiation, and/or conventional radiation and hormonal therapy (if applicable), has on prostate cancer that has already returned or the risk of prostate cancer returning.
Eligibility
- Age range
- 18+ years
- Sex
- Male
- Healthy volunteers
- No
Inclusion Criteria: * Prostate cancer treated primarily with open, laparoscopic or robotically assisted prostatectomy. * Maximum PSA value of 20 ng/ml. Exclusion Criteria: * Evidence of distant metastasis (M1). * Prior systemic chemotherapy for any reason. * Previous irradiation to the pelvis that would compromise the ability to deliver the prescribed study treatment. * Active inflammatory bowel disease (Crohn's disease, diverticulitis or ulcerative colitis) affecting the rectum. (Non-active diverticulitis and Crohn's disease not affecting the rectum are allowed). * History of hip replaceme…
Interventions
- RadiationIMRT to 45 Gy; prostate bed proton boost of 21.6 CGE
Postop High Risk
- RadiationProton (prostate bed) to 70.2 CGE
Salvage Non-High Risk
- RadiationIMRT to 45 Gy; proton boost to prostate bed to 25.2 CGE
Salvage High Risk
- RadiationProton to 66.6 CGE
Post-Op Non High Risk
Locations (4)
- Proton Center of ArkansasLittle Rock, Arkansas
- University of Florida Proton Therapy InstituteJacksonville, Florida
- Northwestern Medicine Chicago Proton CenterWarrenville, Illinois
- Inova Schar Cancer InstituteFairfax, Virginia