Relative Abundance and Spatial Distribution of Lipids and Proteins in Nonalcoholic Fatty Liver Disease (NAFLD)

Vanderbilt University

Summary

Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in the United States. The incidence of NAFLD is very similar to that of obesity, type 2 diabetes, and the metabolic syndrome. The investigators hypothesize that there may be a relationship between over-nutrition, decreased physical activity and the development of fatty liver. The purpose of this study is to identify the types of fats and proteins, and the quantity of each, that are associated with increased severity of NAFLD.

Eligibility

Age range: 18–65 years
Sex: Female
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: * 18-65 year of age * Undergoing elective abdominal or bariatric surgery * May have normal or elevated ALT/AST levels Exclusion Criteria: * Presence of viral hepatitis * Significant alcohol use * Intercurrent infections * Use of any thiazolidinediones

Location

Vanderbilt University Medical Center
Nashville, Tennessee

Relative Abundance and Spatial Distribution of Lipids and Proteins in Nonalcoholic Fatty Liver Disease (NAFLD)

Summary

Eligibility

Location

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Details

Conditions