Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies
National Cancer Institute (NCI)
Summary
Background: \- Laboratory investigators who are studying common childhood cancers are interested in developing a tissue repository to collect and store blood, serum, tissue, urine, or tumors of children who have cancer or adults who have common childhood cancers. To develop this repository, additional samples will be collected from children and adults who have been diagnosed with common childhood cancers such as leukemia and tumors of the central nervous system. Objectives: \- To collect and store blood, serum, tissue, urine, or tumor samples of children who have cancer or adults who have common childhood cancers. Eligibility: * Individuals who have been diagnosed with a common childhood cancer (e.g., leukemia) regardless of patient age. * Children, adolescents, and adults who have been diagnosed with a type of cancer more commonly found in adults. Design: * Extra blood, serum (the liquid part of blood), tissue, urine, or tumor samples will be collected from participants at a time when sampling is required for medical care or as part of a research study. * No additional procedures will be performed for the sole purpose of obtaining additional tumor tissue, aside from what is required for clinical care.
Description
Background: -Laboratory-based investigations have contributed to an improved understanding of the biology of cancer and to the development of new therapies for pediatric malignancies. Objectives: -Systematic Molecular, Genomic, Proteomic, Metabolomic ("Omic") and other profiling for enrolled subjects where omics refers to mechanistic studies using a set of advanced technologies to capture comprehensive aspects of biological systems providing insights into structure, function and interactions to understand these complex processes and diseases better. Eligibility: Pediatric or Adult subject…
Eligibility
- Age range
- 0+ years
- Sex
- All
- Healthy volunteers
- Yes
* SUBJECT INCLUSION CRITERIA: Pediatric or adult subjects with one of the following: * Diagnosis of any tumor, malignancy, pre-malignant disorder, or suspected premalignant familial syndromes, regardless, of patient age; * Biological relatives of any patient with a tumor, malignancy, pre-malignant disorder, or suspected familial pre-malignant syndrome, regardless of patient age or the diagnosis of an adult malignancy or pre-malignant disorder; * Healthy Volunteer without history of malignancy nor a family member currently being treated for cancer who are undergoing surgery, treatment or duri…
Locations (5)
- Children's National Medical CenterWashington D.C., District of Columbia
- Children's Hospital of Orange County (CHOC Children's)Orange, Florida
- National Institutes of Health Clinical CenterBethesda, Maryland
- Tisch Cancer Institute, Mount Sinai Medical CenterNew York, New York
- Carolinas Medical Center/Levine Children's HospitalCharlotte, North Carolina