A Phase III Randomized Study Comparing Intensity Modulated Planning Versus 3-Dimensional Planning for Accelerated Partial Breast Radiotherapy
Rocky Mountain Cancer Centers
Summary
In the setting of radiotherapy as part of breast-conservation therapy for patients with early stage breast cancer, the novel planning and delivery method of intensity modulated radiotherapy is an effective and safe alternative to the commonly-used standard 3D-conformal external beam radiotherapy, spares more normal breast and lung tissue, and may lead to improved clinical outcomes.
Eligibility
- Age range
- 40+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Histologically confirmed disease (AJC Classification): Tis, T1, T2 (≤ 3.0 cm), N0, M0. * Microscopic multifocal disease is only allowed when the entire span of identified disease measures 3.0 cm or less. * Negative surgical margins ( ≥ 0.2 cm) after final surgery. * Subjects with infiltrating lobular histologies or high nuclear grade DCIS will be required to have breast MRI scanning as part of the initial staging to verify localized disease. * Subjects with DCIS will be included in the study only if they had an MRI prior to lumpectomy. * Findings on MRI scanning revealin…
Interventions
- Radiationaccelerated partial breast irradiation - 3D-conformal planning
38.5 Gy, 10 fractions over 5 days
- Radiationaccelerated partial breast irradiation - IMRT planning
38.5 Gy, 10 fractions over 5 days
Locations (5)
- Rocky Mountain Cancer Centers - AuroraAurora, Colorado
- Rocky Mountain Cancer Centers - BoulderBoulder, Colorado
- Rocky Mountain Cancer Centers - LakewoodLakewood, Colorado
- Rocky Mountain Cancer Centers - LittletonLittleton, Colorado
- Rocky Mountain Cancer Centers - ThorntonThornton, Colorado