Treatment Trial of Droxidopa and Pyridostigmine to Improve Orthostatic Hypotension Without Aggravating Supine Hypertension

Inclusion Criteria 1. The presence of OH (fall in systolic BP \>=30 mm Hg) is required for this study. 2. Autonomic testing and clinical evaluation demonstrates OH to be of neurogenic etiology. Exclusion Criteria: 1. Pregnant or lactating females. 2. Chronic illnesses or the presence of other conditions that potentially involve the CNS or affect autonomic testing. These include congestive heart failure, recent (\<6 months) myocardial infarct, severe anemia, diabetes mellitus, alcoholism, malignant neoplasms, amyloidosis, hypothyroidism, sympathectomy, cerebrovascular accidents, and neurotox…