Database Registry to Examine Brain Connections and Brain Function in Mental Disorders and Neural Network Biomarkers for Relational Memory and Psychosis in Schizophrenia
University of Texas Southwestern Medical Center
Summary
Several observations have been made with magnetic resonance imaging (MRI) that characterize brain connections and brain function in individuals with schizophrenia and other mental disorders. For example, research investigating schizophrenia focuses on the dysfunction of connections within and between the medial temporal lobe and the prefrontal cortex as well as other pertinent brain regions. This database registry will allow for the collection of clinical interview data, behavioral data, blood, magnetic resonance imaging (MRI) data, and functional magnetic resonance imaging (fMRI) data on individuals with and without mental disorders to better understand how connections in the brain and various brain regions function differently while volunteers perform various cognitive tasks. This is an observational study that is being conducted to collect data and place it in a registry for current and future investigational questions related to imaging in mental disorders.
Description
The proposed project entails the collection of clinical interview data, behavioral data, blood, magnetic resonance imaging (MRI) data, and functional magnetic resonance imaging (fMRI) data from 1000 volunteers, both patient volunteers and healthy normal volunteers. These data will be used for current and future investigations to better understand how the brains of those with mental disorders process differently that brains of healthy volunteers. The volunteers will undergo a series of clinical interviews to determine their diagnosis, behavioral task training, medical workup, and standard struc…
Eligibility
- Age range
- 18–60 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Volunteers with Schizophrenia or other mental illness * Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnosis of Schizophrenia or Schizoaffective disorder * Competent to give informed consent * All races and ethnicities * Eyesight corrected to 20-40 or better * Able to read, speak, and understand English Healthy volunteers * No past or current severe mental illness * All races and ethnicities * Eyesight corrected to 20-40 or better * Able to read, speak, and understand English Exclusion Criteria: Volunteers with schizo…
Location
- University of Texas Southwestern Medical CenterDallas, Texas