Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
Mayo Clinic
Summary
The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart. Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person.
Description
Study question: Do mutations within certain genes cause or confer susceptibility to spontaneous coronary artery dissection (SCAD)? Specific aims: 1. Create a genomic DNA and plasma biobank for individuals diagnosed with SCAD. 2. Identify inherited and de novo/new mutations that underlie SCAD. 3. Identify common genetic variants that confer risk for SCAD. Long term objective:Discover molecular and cellular mechanisms of SCAD and develop biomarkers to enable prediction and prevention. The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause tears in…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Men and women able to give informed consent and complete a 2 page questionnaire * Diagnosis of one or more episodes of spontaneous coronary artery dissection (SCAD) * Biological parent of individual with SCAD * Relative with fibromuscular dysplasia, arterial aneurysm, or arterial dissection Exclusion Criteria: * Lack of confirmation of SCAD diagnosis
Location
- Mayo ClinicRochester, Minnesota