Assessment of Reorganization and Plasticity of Eloquent Function in Patients With Brain Tumors
University of Nebraska
Summary
Purpose of the study: AIM 1: Prospectively collect pre-operative \[functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)\] and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other. AIM 2: Assess reorganization of eloquent brain function and plasticity in patients with intra-axial brain tumors. This will be accomplished by prospectively collecting post-operative mapping studies and neuropsychological tests to compare them to prior mapping studies as stated above.
Description
Any patient with a primary or metastatic brain tumor in or near an eloquent area would be eligible for participation in the study assuming no contraindications to any of the studies or operative procedure. Pre-operative evaluation will include clinical evaluation, neuropsychological testing, magnetic resonance imaging (MRI) brain with and without contrast, fMRI, DTI tractograms, and MEG studies as well as standard pre-operative work-up. Intra-operative procedures include all non-invasive pre-operative mapping data being incorporated into the operative procedure with imaging tools that are ro…
Eligibility
- Age range
- 19+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * 19 years and older * Brain tumor in or near eloquent brain regions that is appropriate for attempted resection * Appropriate body habitus and mental status/capacity to participate with non-invasive or invasive mapping * Benign or malignant intra-axial brain tumor * Primary or metastatic intra-axial brain tumor Exclusion Criteria: * Any contraindication to MRI (i.e. implanted devices) * Inappropriate body habitus or mental status/capacity to participate with non-invasive or invasive mapping in a safe and reliable manner * Declining to participate * Lacks capacity to und…
Interventions
- Diagnostic TestBrain mapping
Brain mapping will be employed pre-, intra-, and post-operatively to evaluate specific functions.
Location
- University of Nebraska Medical CenterOmaha, Nebraska