The Cleveland Clinic
The overall goal of the Asthma Inflammation Research \[AIR\] Translational Program is to create an integrated multidisciplinary team for the focused purpose of development of diagnostic and prognostic tests informative for airway inflammation, and for the design of innovative, targeted biologic therapeutics. The overarching aims of the AIR program are to conceptualize, develop, and test the next-generation therapeutics, and novel asthma diagnostic and prognostic tools that will allow us to improve the standard of asthma care.
More than 20 million Americans suffer from asthma, and nearly half of asthma sufferers do not have their asthma under control. Although commonly diagnosed using physiological measures of airflow and bronchial hyperreactivity, asthma pathophysiology is related to chronic inflammation of the airway. Current diagnostic evaluation and monitoring are inadequate for proposed practice guidelines. The most commonly used test for evaluation of asthma is the measurement of airflow obstruction by spirometry. The National Asthma Education Prevention Program (NAEPP) and Expert Panel Reports set forth grad…
Inclusion Criteria: * Asthma diagnosed by a medical specialist and/or history of positive methacholine rest and/or reversibility of \>10% of FEV1 * FEV1 is within acceptable limits * Informed Consent is present Exclusion Criteria: * Diabetes (fasting blood sugar \>110 mg/dL) * Any milk allergies * Coconut allergies * BMI \>40 kg/m2, * Inability to maintain diet intervention * Current smoking or smoking history of greater than 10 pack-years * Any other significant respiratory or cardiac disease or the presence of clinically important comorbidities, including, uncontrolled coronary artery dis…
participants will be provided a medium chain triglyceride supplement or placebo
participants will be provided a low caloric dietary shake
inhalation of allergens by allergic patients with or without asthma, will be used to define mechanisms underlying the development of airway inflammation
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