Gene Expression in Isolates of Group A Streptococci Recovered From Patients Who Are Carriers
University of Wisconsin, Madison
Summary
The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.
Description
The overall objective of this investigation is to understand the differences in Group A streptococci in children who are acutely infected from those who are carriers. The hypothesis is that when in the carrier state, GAS exhibits unique transcriptional profiles that differ from those of the acute infection state. The investigators expect transcriptional profiles of GAS to provide important information regarding the changes the organism undergoes when transitioning between acute infection and carriage. The specific aims of this study are: 1. To collect longitudinal participant-samples from ac…
Eligibility
- Age range
- 5–15 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Children ages 5-15 years * Positive rapid antigen detection test for group A streptococcus * Parent or legal guardian present and able to provide consent * Provider prescribes treatment with a beta lactam antibiotic * English speaking Exclusion Criteria: * Unable to take beta lactam antibiotics * Other concurrent bacterial infection, i.e., pneumonia
Interventions
- OtherIdentifying group A strep carriers
At study entry, at 14 days, and if follow up is positive, again in 14-21 days: Standard culture for GAS and analysis of mRNA.
Location
- UW Health Pediatric ClinicsMadison, Wisconsin