Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program
M.D. Anderson Cancer Center
Summary
This study performs standardized testing of tumor tissue samples to learn which genes are mutated (have changed) in order to provide personalized cancer therapy options to cancer patients at MD Anderson. This may help doctors use testing information on tumors to identify clinical trials that may be most relevant to patients. Researchers may also use the information learned from this study to develop a database of the different kinds of mutations in cancer-related genes.
Description
PRIMARY OBJECTIVES: I. To perform molecular analysis for patients at MD Anderson to assist in personalized cancer therapy. II. To determine the frequency of mutations, co-mutations and, other alterations including germline polymorphism and deleterious mutations (germline genetic factors), in cancer-related genes within different tumor types, and to determine patient preference for return of results. III. To establish a database of somatic mutations, copy number alterations, gene fusion/translocation information and other biomarker alterations and clinical characteristics that can be used to…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients must have histologically, radiographic, or cytologically documented cancer, suspected glioma, sarcoma, melanoma or hematologic cancer. Patients with benign tumors may also be consented at the discretion of the attending physician if molecular profiling is felt to have potential clinical implications. * Patients must have the ability to understand and the willingness to sign a written informed consent document * Patients may be consented without confirming the amount and quality of archival diagnostic or residual tissue available. However, research testing will o…
Interventions
- ProcedureBiospecimen Collection
Undergo collection of blood, saliva/buccal swab samples
- OtherGenetic Testing
Correlative studies
- OtherMedical Chart Review
Review of medical records
Location
- M D Anderson Cancer CenterHouston, Texas