Autologous Orthotopic Transplantation of Previously Cryopreserved Ovarian Tissue
Abramson Cancer Center at Penn Medicine
Summary
Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preserve future fertility (protocol 806062). The primary objective of this study is to determine the efficacy and safety of autologous transplantation of previously cryopreserved ovarian cortical tissue in patients who experience infertility or ovarian insufficiency after cancer treatments.
Eligibility
- Age range
- 18–45 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Female patient between the ages of 18 and 45 years * Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation * Ovarian insufficiency defined as an elevated FSH over 10 * Inability to conceive after 6 months of unprotected intercourse with male * Reasonably good health * Candidate for pregnancy * Written clearance for the procedure from the patients oncologist Exclusion Criteria: * Patients considered to be high risk for surgical complications will be excluded from the research protocol * Women who are known to be positive fo…
Interventions
- ProcedureTransplantation of previously cryopreserved ovarian tissu
Location
- Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, Pennsylvania