A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma
Beth Israel Deaconess Medical Center
Summary
CyberKnife Based Radiosurgery is a way to deliver large doses of radiation very accurately to a tumor. The ability of this technology to minimize radiation dose to organs adjacent to the target tumor allows a high dose to be delivered to the tumor, thus potentially increasing the efficacy of radiation treatment. Currently, radiosurgery is commonly used for brain metastases, Stage I lung cancer, spine tumors, and localized prostate cancer. The purpose of this protocol is to evaluate the role of Radiosurgery for the treatment of clinically localized primary renal cell carcinoma.
Description
Before the research starts (screening) Many of these tests and procedures are likely to be part of regular cancer care and may be done even if it turns out that you do not take part in the research study. If you have had some of these tests or procedures recently, they may or may not have to be repeated. * A medical history, which includes questions about your health, current medications, and any allergies. * Performance status, which evaluates how you are able to carry on with your usual activities. * Quality of life survey. * Gold seed (Fiducial) Placement: Placement of at least one (usuall…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Participants must meet the following criteria on screening examination to be eligible to participate in the study: * Participants must have histologically or radiological evidence of Stage I (T1N0M0) renal cell carcinoma with a size no larger than 8 cm in greatest dimension measured by MRI or CT Scan * At least one (usually up to 3) gold fiducial placed in or around tumor, can be performed on the same day - after signing research informed consent. * No irreversible coagulopathies * Age ≥ 18 years old because no dosing or adverse event data are currently available on the…
Interventions
- DeviceCyberKnife
Stereotactic Body Radiation Therapy. 3 or 4 fractions of radiotherapy delivered by Cyberknife.
Location
- Beth Israel Deaconess Medical CenterBoston, Massachusetts