Observational Study of Ocular Blood Flow Pre- and Post- Glaucoma Surgery Using Functional and Structural Optical Coherence Tomography
Oregon Health and Science University
Summary
The purpose of this study is to determine if lowering the pressure inside the eye improves blood flow to the eye.
Description
Using high-speed ocular coherence tomography (OCT) systems, we have developed new methods to image and measure optic nerve head (ONH) and retinal blood flow. Preliminary results have shown that visual field (VF) loss is more highly correlated with retinal blood flow as measured by OCT than any neural structure measured by OCT or other imaging modality. Accordingly, the goal of the proposed project is to improve the diagnostic and prognostic evaluation of glaucoma by further developing novel functional OCT measurements using ultrahigh-speed (70-100 kHz) OCT technology. Retinal blood flow, ONH…
Eligibility
- Age range
- 18–85 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Subjects diagnosed with perimetric open angle glaucoma or chronic angle closure glaucoma. * Subjects scheduled to undergo trabeculectomy or tube shunt surgery Exclusion Criteria: * Best-corrected visual acuity less than 20/40 * Age \< 18 or \>85 years * Refractive error of \> +3.00 D or \< -7.00 D * Previous vision correction surgery such as Laser-Assisted in situ Keratomileusis (LASIK) or Photorefractive Keratectomy (PRK) * Previous intraocular surgery except for uncomplicated cataract extraction with posterior chamber intraocular lens implantation * Diabetic retinopa…
Location
- OHSUPortland, Oregon