MemorialCare Health System
The purpose of this study is to find out whether giving a short course of focused radiation called an SBRT "boost" is a safe and effective way to treat prostate cancer. This boost delivers a high dose of radiation to the prostate in a non-invasive way, similar to what is done with high dose rate (HDR) brachytherapy but without using needles. The study looks at how well this treatment controls the cancer, what side effects it may cause, and how it affects patients' quality of life over time.
This study is designed to evaluate whether delivering a stereotactic body radiotherapy (SBRT) boost-a short course of five high-dose, precisely targeted radiation treatments-can safely and effectively replace the traditional invasive high dose rate (HDR) brachytherapy boost for men with unfavorable, high-risk, or very high-risk localized prostate cancer. The SBRT boost uses imaging-guided systems and gold fiducial markers to track prostate motion in real time, allowing submillimeter accuracy without placing needles inside the prostate. Treatment planning incorporates CT/MRI fusion, careful map…
Inclusion * Histologically proven prostate adenocarcinoma * Biopsy within 12 months of date of registration required except for patients who already meet criteria for enrollment in the high risk arm of the protocol. For these patients, repeat biopsy will be at the discretion of the treating physician. In general, repeat biopsy is recommended for these patients, but is not required if it will not affect the treating physician's management decisions in regards to the care of the patient. * Clinical Stage I-IV, MX-M0 (AJCC VERSION 9) * M-stage determined by physical exam, CT, MRI, bone scan, PSM…
The intervention in this study is the SBRT boost, which is a short course of five high-dose stereotactic body radiotherapy treatments (5.5 Gy × 5 fractions, total 27.5 Gy) delivered with image-guided precision to the prostate. This SBRT boost is given in addition to standard external-beam radiation therapy (EBRT), which delivers 50.4 Gy to the pelvis, prostate, and proximal seminal vesicles.
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