Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
University of Washington
Summary
Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.
Description
This is a prospective randomized interventional study comparing four current standard-of-care treatments for chalazia: incision and curettage, local injection of triamcinolone, local injection of 5-FU, and local injection of combination triamcinolone/5-FU.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Single or multiple chalazia in a single eyelid Exclusion Criteria: * Chalazia present for less than one month and no previous injection or incision and curettage
Interventions
- Drug5-fluorouracil Injection
If the chalazion is present at follow-up visit, another injection of 5-FU will be given.
- DrugTriamcinolone Acetonide
If chalazion present at follow-up, another Triamcinolone injection will be done.
- ProcedureIncision and Curettage
If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.
- DrugTriamcinolone Acetonide/5-fluorouracil mixture
If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.
Location
- University of Washington Eye Institute at HarborviewSeattle, Washington